 |
 |
| |
1 ampoules : isosorbide dinitrate 10mg/10ml (0.1%)
1 bottle : isosorbide dinitrate 50mg/50ml (0.1%) |
| |
 |
| |
Unresponsive left ventricular failure
Acute myocardial infarction
Severe or unstable angina pectoris
Pulmonary edema |
| |
 |
| |
|
0,1mg ISDN/ml (0.01%)
5 ampoules or 1X50ml bottle made up to 500ml |
|
0,2mg ISDN/ml (0.02%)
10 ampoules or 2X50ml bottle made up to 500ml |
|
FLOW RATE |
DOSAGE FORESEEN |
FLOW RATE |
|
μ drops/min
ml
/hour |
drops/min
|
mg
/hour |
μ drops/min
ml
/hour |
drops/min
|
|
10 |
3~4 |
1 |
5 |
1~2 |
|
20 |
7 |
2 |
10 |
3 |
|
30 |
10 |
3 |
15 |
5 |
|
40 |
13 |
4 |
20 |
7 |
|
50 |
17 |
5 |
25 |
8 |
|
60 |
20 |
6 |
30 |
10 |
|
70 |
23 |
7 |
35 |
12 |
|
80 |
27 |
8 |
40 |
13 |
|
90 |
30 |
9 |
45 |
15 |
|
100 |
33 |
10 |
50 |
17 |
|
| |
 |
| |
Whilst sharp falls in systemic arterial pressure can give rise to
symptoms of cerebral flow deficiency and decreased coronary
perfusion, clinical experience with isoket infusion has shown
that this is not normally a problem. This is consistent with the
known vasodilatory effects of isosorbide dinitrate which occur
predominantly on the venous rather than on the arterial side of
the circulation. In common with other nitrates, headaches and
nausea may occur during administration. |
| |
 |
|
|
Isoket I.V should not be administered
in cases of
-circulatory collapse and severe hypotension
-in patients with known sensitivity to nitrates.
-in patients with marked anaemia, head trauma, cerebral
hemorrhage, severe hypotension or hypovolemia. |
| |
 |
| |
Close attention to pulse and blood pressure is necessary
during the administration of isoket infusion.
Isoket infusion should be used with caution in patients who are
predisposed to closed angle glaucoma.
Isoket should be used with caution in patients suffering from
hyperthyroidism, malnutrition, severe liver or renal disease or
hypothermia. |
| |
